Findings

What do systematic reviews say?

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Any adverse event · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in any adverse event compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Anti‐cytokine targeted therapies for ANCA‐associated vasculitis 2020 · Cochrane Headline outcomes only
RR 1.12 [0.97, 1.29]
Studies not reported
Low

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Any severe or serious AE (grade 3, 4 or 5) · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in any severe or serious AE (grade 3, 4 or 5) compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Anti‐cytokine targeted therapies for ANCA‐associated vasculitis 2020 · Cochrane Headline outcomes only
RR 1 [0.8, 1.27]
Studies not reported
Low

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

Withdrawals due to adverse events · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy may leads to higher any withdrawals due to AE compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Anti‐cytokine targeted therapies for ANCA‐associated vasculitis 2020 · Cochrane Headline outcomes only
RR 2.66 [1.07, 6.59]
Studies not reported
Low

Active drug (etanercept or belimumab) with standard therapy vs placebo + standard care

MortalityNumber of participants: 285(2 RCTs) WGET 2005 · adults (age 18 years and older) with GPA ANCA‐associated vasculitis or microscopic polyangiitis (only a subset of patients in one study,…

Active drug (etanercept or belimumab) with standard therapy showed no clear difference in mortalityNumber of participants: 285(2 RCTs) WGET 2005 compared with standard therapy with placebo (low certainty).

1 finding from 1 review

Anti‐cytokine targeted therapies for ANCA‐associated vasculitis 2020 · Cochrane Headline outcomes only
Peto OR 2.45 [0.55, 10.97]
Studies not reported
Low

Summary of findings: Additional exercise plus physiotherapy vs usual physiotherapy

Rate of falls Length of · and

1 finding from 1 review

Interventions for preventing falls in older people in care facilities and hospitals 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 215 participants
Very low

Summary of findings: Additional exercise plus physiotherapy vs usual physiotherapy

Risk of falling Length of · and

It is very uncertain whether summary of findings: Additional exercise plus physiotherapy changes risk of falling Length of compared with usual physiotherapy (very low certainty).

1 finding from 1 review

Interventions for preventing falls in older people in care facilities and hospitals 2018 · Cochrane Headline outcomes only
RR 0.36 [0.14, 0.93]
2 studies · 83 participants
Very low

Summary of findings: Additional exercise plus physiotherapy vs usual physiotherapy

Fracture · and

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing falls in older people in care facilities and hospitals 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Additional exercise plus physiotherapy vs usual physiotherapy

Adverse events Length of · and

1 finding from 1 review

Interventions for preventing falls in older people in care facilities and hospitals 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 161 participants
Very low

CBT vs anxiety management

Outcomes · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)

The review found no eligible studies for this question.

1 finding from 1 review

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CBT vs anxiety management

Treatment efficacy (change in OCD score), end of treatment. Measured by Y‐BOCs Score · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)

1 finding from 1 review

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

CBT vs anxiety management

Dropout · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)

Cognitive behavioural therapy showed no clear difference in total number of dropouts, end of treatment compared with anxiety management (low certainty).

1 finding from 1 review

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
RR 1 [0.22, 4.45]
1 study · 46 participants
Low

CBT vs anxiety management

Quality of life, end of treatment Measured by WSAS Score · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)

1 finding from 1 review

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

CBT vs anxiety management

Depressive symptoms · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)

1 finding from 1 review

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

CBT vs anxiety management

Severity of anxiety symptoms, end of treatment Measured by BDI Score · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)

1 finding from 1 review

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

CBT vs anxiety management

Behavioural difficulties, end of treatment · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)

The review found no eligible studies for this question.

1 finding from 1 review

Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CBT vs no treatment or treatment

Recidivism: any sexual or nonsexual offence (no study reported data on this outcome) · young people (aged 10 to 18 years old) with harmful sexual behaviour

The review found no eligible studies for this question.

1 finding from 1 review

Cognitive‐behavioural therapy (CBT) interventions for young people aged 10 to 18 with harmful sexual behaviour 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CBT vs alternative interventions

Sexual attitudes and behaviour · young people (aged 10 to 18 years old) with harmful sexual behaviour

1 finding from 1 review

Cognitive‐behavioural therapy (CBT) interventions for young people aged 10 to 18 with harmful sexual behaviour 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

CBT vs alternative interventions

Thinking patterns (no study reported data on this outcome) · young people (aged 10 to 18 years old) with harmful sexual behaviour

The review found no eligible studies for this question.

1 finding from 1 review

Cognitive‐behavioural therapy (CBT) interventions for young people aged 10 to 18 with harmful sexual behaviour 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CBT vs alternative interventions

Victim empathy (no study reported data on this outcome) · young people (aged 10 to 18 years old) with harmful sexual behaviour

The review found no eligible studies for this question.

1 finding from 1 review

Cognitive‐behavioural therapy (CBT) interventions for young people aged 10 to 18 with harmful sexual behaviour 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CBT vs alternative interventions

Social functioning · young people (aged 10 to 18 years old) with harmful sexual behaviour

The review found no eligible studies for this question.

1 finding from 1 review

Cognitive‐behavioural therapy (CBT) interventions for young people aged 10 to 18 with harmful sexual behaviour 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found