Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Clinical improvement: participants discharged from hospital ‐ not reported · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in improvement of clinical status (number of participants discharged… compared with saline placebo (low certainty).

1 finding from 1 review

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Adverse events: all grades · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in adverse events of any grade (by day 28) compared with saline placebo (low certainty).

1 finding from 1 review

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Serious adverse events (by day 28) · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in serious adverse events (by day 28) compared with saline placebo (low certainty).

1 finding from 1 review

Hyperimmune immunoglobulin from human plasma vs saline placebo

Worsening of clinical status at day 28 (data only available for clinical status worsened on day 7) · individuals with moderate or severe COVID‐19

It is very uncertain whether hyperimmune immunoglobulin from human plasma changes worsening of clinical status at day 28 (data only available for… compared with saline placebo (very low certainty).

1 finding from 1 review

Hyperimmune immunoglobulin from human plasma vs saline placebo

Serious adverse events up to day 28 (data available only as a composite of serious adverse events or death up to day 28) · individuals with moderate or severe COVID‐19

Hyperimmune immunoglobulin from human plasma showed no clear difference in serious adverse events up to day 28 (data available only as a… compared with saline placebo (low certainty).

1 finding from 1 review

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

All‐cause mortality (by day 28) · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in all‐cause mortality (by day 28) compared with saline placebo (low certainty).

1 finding from 1 review

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Worsening of clinical status (expressed as new need for IMV, admission to ICU, or death by day 28) · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in worsening of clinical status (expressed as new need for IMV,… compared with saline placebo (low certainty).

1 finding from 1 review

Obesity Class III vs Normal Weight or Non‐Obese

Hospitalisation (30 days, community) · Adults with COVID‐19

Obesity Class III may leads to higher hospitalisation (adjusted for DM, HTN, cardiovascular disease, age,… compared with normal BMI, Non‐obese, or BMI < 40 (low certainty).

2 findings from 1 review

Intervention not reported

Anthropometric recovery Defined as: WHZ ≥ −1.5 or MUAC > 125 mm for 2 consecutive visits and absence of nutritional oedema for 14 days (Alvarez Moran 2018b); absence of oedema and WHZ ≥ −1.5 or MUAC > 125 mm (Charle‐Cuellar 2021c; no oedema and we... · children aged > 6 months and < 5 years with wasting

It is very uncertain whether the intervention changes anthropometric recovery Defined as: WHZ ≥ −1.5 or MUAC > 125 mm for… (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐response to treatment Defined as: not achieving weight‐for‐height > 85% of ideal or relapse requiring inpatient treatment (Linneman 2007)a; persistent oedema at 21 days or no weight gain in 2 consecutive visits (Ogobara Dougnon 2021)d; not mee... · children aged > 6 months and < 5 years with wasting

It is very uncertain whether the intervention changes non‐response to treatment Defined as: not achieving… (very low certainty).

1 finding from 1 review