Findings

What do systematic reviews say?

1,938 questions · 2,020 findings · 107 reviews

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No studies found 570 · 28.2%GRADE not reported 266 · 13.2%Very low 578 · 28.6%Low 462 · 22.9%Moderate 118 · 5.8%High 26 · 1.3%

Pregabalin or Gabapentin vs control or placebo medications

Length of critical care stay (hours) · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pregabalin or Gabapentin vs control or placebo medications

Length of hospital stay · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Very low

Pregabalin or Gabapentin vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Pregabalin or Gabapentin may leads to lower adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 273 participants
Low

Acetaminophen vs control or placebo medications

Acute postoperative pain 0 to 6 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 332 participants
Moderate

Acetaminophen vs control or placebo medications

Acute postoperative pain at 12 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 332 participants
Moderate

Acetaminophen vs control or placebo medications

Acute postoperative pain at 24 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 459 participants
High

Acetaminophen vs control or placebo medications

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 202 participants
Very low

Acetaminophen vs control or placebo medications

Analgesia requirements · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 459 participants
High

Acetaminophen vs control or placebo medications

Analgesic Success · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs control or placebo medications

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 149 participants
Very low

Acetaminophen vs control or placebo medications

Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 131 participants
Very low

Acetaminophen vs control or placebo medications

Chronic Headache · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acetaminophen vs control or placebo medications

Length of critical care stay (hours) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 131 participants
Very low

Acetaminophen vs control or placebo medications

Length of hospital stay · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 335 participants
Moderate

Acetaminophen vs control or placebo medications

Adverse events · adults undergoing brain surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Scalp infiltration vs placebo or control

Acute postoperative pain 0 to 6 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 475 participants
Moderate

Scalp infiltration vs placebo or control

Acute postoperative pain at 12 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 309 participants
Low

Scalp infiltration vs placebo or control

Acute postoperative pain at 24 hours (Score 0 to 10, VAS or NRS Scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 260 participants
Moderate

Scalp infiltration vs placebo or control

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 128 participants
Moderate

Scalp infiltration vs placebo or control

Analgesia requirements · adults undergoing brain surgery

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 345 participants
Very low