All‐cause mortality at day 28 · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma showed no clear difference in all‐cause mortality at day 28 compared with saline placebo (low certainty).
1 finding from 1 review
RR 0.79 [0.43, 1.44]
Studies not reported
Low
Clinical improvement: participants discharged from hospital ‐ not reported · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in improvement of clinical status (number of participants discharged… compared with saline placebo (low certainty).
1 finding from 1 review
Adverse events: all grades · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in adverse events of any grade (by day 28) compared with saline placebo (low certainty).
1 finding from 1 review
Grades 3 and 4 adverse events · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… led to higher adverse events at grade 3 or 4 (by day 28) compared with saline placebo; GRADE not reported.
1 finding from 1 review
OR 4
3 participants
GRADE not reported
Serious adverse events (by day 28) · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in serious adverse events (by day 28) compared with saline placebo (low certainty).
1 finding from 1 review
Worsening of clinical status at day 28 (data only available for clinical status worsened on day 7) · individuals with moderate or severe COVID‐19
It is very uncertain whether hyperimmune immunoglobulin from human plasma changes worsening of clinical status at day 28 (data only available for… compared with saline placebo (very low certainty).
1 finding from 1 review
RR 0.85 [0.58, 1.23]
Studies not reported
Very low
Adverse events: all grades · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma showed no clear difference in adverse events of any grade up to 28 days (data only available for… compared with saline placebo (low certainty).
1 finding from 1 review
RR 0.98 [0.81, 1.18]
Studies not reported
Low
Grades 3 and 4 adverse events · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma probably leads to higher adverse events at grades 3 to 4 up to 28 days compared with saline placebo (moderate certainty).
1 finding from 1 review
RR 4.09 [1.39, 12.01]
Studies not reported
Moderate
Serious adverse events up to day 28 (data available only as a composite of serious adverse events or death up to day 28) · individuals with moderate or severe COVID‐19
Hyperimmune immunoglobulin from human plasma showed no clear difference in serious adverse events up to day 28 (data available only as a… compared with saline placebo (low certainty).
1 finding from 1 review
RR 0.72 [0.45, 1.14]
Studies not reported
Low
All‐cause mortality (by day 28) · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in all‐cause mortality (by day 28) compared with saline placebo (low certainty).
1 finding from 1 review
Worsening of clinical status (expressed as new need for IMV, admission to ICU, or death by day 28) · individuals with moderate or severe COVID‐19
RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in worsening of clinical status (expressed as new need for IMV,… compared with saline placebo (low certainty).
1 finding from 1 review
Hospital admissions · Adults with COVID‐19
Obesity Class II probably leads to higher hospitalisation(30‐days, community) compared with normal Weight or Non‐Obese (moderate certainty).
1 finding from 1 review
Hospitalisation (30 days, community) · Adults with COVID‐19
Obesity Class III may leads to higher hospitalisation (adjusted for DM, HTN, cardiovascular disease, age,… compared with normal BMI, Non‐obese, or BMI < 40 (low certainty).
2 findings from 1 review
Hospital admissions · Adults with COVID‐19
Obesity (Unclassified) probably leads to higher hospitalisation (adjusted for age, sex, DM, HTN, and cardiovascular… compared with normal Weight or Non‐Obese (moderate certainty).
1 finding from 1 review
Severe COVID · Adults with COVID‐19
Obesity (Unclassified) leads to higher severe COVID(30‐days, community) compared with normal Weight or Non‐Obese (high certainty).
1 finding from 1 review
Pneumonia · Adults with COVID‐19
Obesity (Unclassified) probably leads to higher pneumonia(30‐days, community) compared with normal Weight or Non‐Obese (moderate certainty).
1 finding from 1 review
Hospitalisation (30 days, community) · Adults with COVID‐19
Obesity (Unclassified) may leads to higher hospitalisation (30 days, community) compared with normal Weight or Non‐Obese (low certainty).
1 finding from 1 review
Hospitalisation (30 days, community) · Adults with COVID‐19
Every 5 units (kg/m2) increase in BMI may leads to higher hospitalisation(30 days, community) compared with N/A (low certainty).
1 finding from 1 review
Hospital admissions · Adults with COVID‐19
Obesity Class I probably leads to lower hospitalisation(30‐days, community) compared with normal Weight or Non‐Obese (moderate certainty).
1 finding from 1 review
Intervention not reported
Anthropometric recovery Defined as: WHZ ≥ −1.5 or MUAC > 125 mm for 2 consecutive visits and absence of nutritional oedema for 14 days (Alvarez Moran 2018b); absence of oedema and WHZ ≥ −1.5 or MUAC > 125 mm (Charle‐Cuellar 2021c; no oedema and we... · children aged > 6 months and < 5 years with wasting
It is very uncertain whether the intervention changes anthropometric recovery Defined as: WHZ ≥ −1.5 or MUAC > 125 mm for… (very low certainty).
1 finding from 1 review