Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,310 questions · 1,358 findings · 214 reviews

No studies found 230 · 16.9%GRADE not reported 169 · 12.4%Very low 269 · 19.8%Low 277 · 20.4%Moderate 291 · 21.4%High 122 · 9%

Abrupt discontinuation deprescribing vs continued use

Lack of symptom control · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes lack of symptom control compared with continued use (very low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Adverse drug withdrawal events ‐ relapse (endoscopic findings) · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).

1 finding from 1 review

Dietary supplements vs placebo

Dill seed versus placebo Pain score · women with moderate or severe primary dysmenorrhoea
11 findings from 1 review
Show 8 more findings

Dietary supplements vs placebo

Relief of pain · women with moderate or severe primary dysmenorrhoea

Dietary supplements may leads to higher zataria versus placebo Pain relief compared with placebo (low certainty).

3 findings from 1 review

Dietary supplements vs placebo

Zinc sulphate versus placebo Adverse effects · women with moderate or severe primary dysmenorrhoea

It is very uncertain whether dietary supplements changes zinc sulphate versus placebo Adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Dietary supplements vs placebo

Ginger versus placebo Adverse effects · women with moderate or severe primary dysmenorrhoea

It is very uncertain whether dietary supplements changes ginger versus placebo Adverse effects compared with placebo (very low certainty).

1 finding from 1 review

MAL‐PDT vs red light only

Investigator's global assessment (IGA) of improvement Treatment 'success' as defined by IGA score decrease5 · Moderate and severe acne vulgaris

MAL‐PDT probably leads to higher investigator's global assessment (IGA) of improvement Treatment… compared with red light only (moderate certainty).

1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    RR 1.74 [1.11, 2.74]
    3 studies · 360 participants
    Moderate

ALA‐PDT vs blue light only

Participant's global assessment of improvement Non‐standardised scale5 · Moderate and severe acne vulgaris

ALA‐PDT showed no clear difference in participant's global assessment of improvement Non‐standardised scale5 compared with blue light only (low certainty).

1 finding from 1 review

ALA‐PDT vs blue light only

Investigator‐assessed change in inflamed lesions (ILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 266 participants
    Very low

ALA‐PDT vs blue light only

Investigator‐assessed percentage change in ILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 266 participants
    Very low

ALA‐PDT vs blue light only

Investigator‐assessed severe adverse effects Application site blister · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 266 participants
    Very low

ALA‐PDT vs blue light only

Investigator's global assessment (IGA) of improvement Treatment 'success' as defined by IGA score decrease5 · Moderate and severe acne vulgaris

ALA‐PDT showed no clear difference in investigator's global assessment (IGA) of improvement Treatment… compared with blue light only (low certainty).

1 finding from 1 review

MAL‐PDT vs red light only

Paticipant's global assessment of improvement ‐ Not measured · Moderate and severe acne vulgaris

The review found no eligible studies for this question.

1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

MAL‐PDT vs red light only

Investigator‐assessed change in inflamed lesions (ILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate