Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,281 questions · 1,307 findings · 212 reviews

No studies found 256 · 19.6%GRADE not reported 125 · 9.6%Very low 266 · 20.4%Low 403 · 30.8%Moderate 208 · 15.9%High 49 · 3.7%

Felbamate plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Felbamate plus ASMs showed no clear difference in number of participants with adverse events leading to study… compared with placebo plus ASMs (low certainty).

1 finding from 1 review

Rufinamide plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Rufinamide plus ASMs showed no clear difference in number of participants with adverse events leading to study… compared with placebo plus ASMs (low certainty).

1 finding from 1 review

Rufinamide plus ASMs vs other ASM plus ASMs

Number of adverse events requiring discontinuation of treatment ‐ not reported · Lennox‐Gastaut syndrome, any age

Rufinamide plus ASMs showed no clear difference in number of participants with treatment‐emergent adverse events… compared with other ASM plus ASMs (low certainty).

1 finding from 1 review