Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

229 questions · 231 findings · 28 reviews

No studies found 32 · 13.9%GRADE not reported 3 · 1.3%Very low 28 · 12.1%Low 58 · 25.1%Moderate 60 · 26%High 50 · 21.6%

Intervention not reported

AIS associated with HPV16/18 or 6/11/16/18 (age 15 to 26 years) · adolescent girls and women aged 15 to 45 years who were HPV16/18 negative before vaccination

The intervention probably leads to lower AIS associated with HPV16/18 or 6/11/16/18 (age 15 to 26 years) (moderate certainty).

1 finding from 1 review

Intervention not reported

Any CIN2+ irrespective of HPV type, bivalent or quadrivalent vaccine · adolescent girls and women aged 15 to 26 years who are hrHPV negative before vaccination

The intervention leads to lower any CIN2+ irrespective of HPV type, bivalent or quadrivalent vaccine (high certainty).

1 finding from 1 review

Intervention not reported

Any CIN3+ irrespective of HPV type, bivalent or quadrivalent vaccine · adolescent girls and women aged 15 to 26 years who are hrHPV negative before vaccination

The intervention showed no clear difference in any CIN3+ irrespective of HPV type, bivalent or quadrivalent vaccine (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of diphtheria, tetanus, pertussis, Haemophilus influenzae type b (Hib) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐severe local reaction10 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to lower non‐severe local reaction10 (moderate certainty).

1 finding from 1 review

Intervention not reported

Fever14 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

It is very uncertain whether the intervention changes fever14 (very low certainty).

1 finding from 1 review

Intervention not reported

Incidence of diphtheria, tetanus, pertussis, Haemophilus influenzae type b (Hib) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

2a. Adequate immune response (seroprotection) against diphtheria (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine

The intervention showed no clear difference in 2a. Adequate immune response (seroprotection) against diphtheria… (moderate certainty).

1 finding from 1 review