Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

170 questions · 174 findings · 17 reviews · Headline outcomes only

No studies found 51 · 29.3%GRADE not reported 30 · 17.2%Very low 22 · 12.6%Low 38 · 21.8%Moderate 22 · 12.6%High 11 · 6.3%

Next‐generation ALK inhibitor vs crizotinib

Progression‐free survival in people with central nervous system disease · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

Next‐generation ALK inhibitor leads to lower progression‐free survival in people with central nervous system… compared with crizotinib (high certainty).

1 finding from 1 review

Intervention not reported

Progression‐free survival (PFS) ‐ Network (subnet 1) included 5 pairwise comparisons ‐ Median · people with a confirmed diagnosis of advanced renal cell carcinoma (RCC) and a favourable risk according to the International Metastatic…
1 finding from 1 review

Intervention not reported

Overall survival (OS) ‐ Network (subnet 1) included 3 pairwise comparisons ‐ Median · people with a confirmed diagnosis of advanced renal cell carcinoma (RCC) and a favourable risk according to the International Metastatic…
1 finding from 1 review

Intervention not reported

Progression‐free survival (PFS) ‐ Network (subnet 1) included 7 pairwise comparisons ‐ Median · people with a confirmed diagnosis of advanced renal cell carcinoma (RCC) and a favourable risk according to the International Metastatic…
1 finding from 1 review

Intervention not reported

Overall survival (OS) ‐ Network (subnet 1) included 10 pairwise comparisons ‐ Median · people with a confirmed diagnosis of advanced renal cell carcinoma (RCC) and an intermediate or poor risk according to the International…
1 finding from 1 review

Intervention not reported

Progression‐free survival (PFS) ‐ Network (subnet 1) included 11 pairwise comparisons ‐ Median · people with a confirmed diagnosis of advanced renal cell carcinoma (RCC) and an intermediate or poor risk according to the International…
1 finding from 1 review