Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

122 questions · 126 findings · 21 reviews · Headline outcomes only

No studies found 23 · 18.3%GRADE not reported 1 · 0.8%Very low 26 · 20.6%Low 44 · 34.9%Moderate 30 · 23.8%High 2 · 1.6%

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Lutein with or without zeaxanthin vs placebo

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo (low certainty).

1 finding from 1 review

Iridotomy vs no iridotomy

Need for additional surgery: proportion of participants who received additional surgery to control IOP at 1 year · people with primary angle‐closure suspect

Iridotomy showed no clear difference in need for additional surgery: proportion of participants who received… compared with no iridotomy (low certainty).

1 finding from 1 review

Intervention not reported

Undercorrected vs fully corrected spectacles · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Systemic 7‐methylxanthine vs placebo · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus multifocal spectacles vs placebo plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus bifocal spectacles vs cyclopentolate plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Bifocal spectacles vs SVLs with timolol drops · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Tropicamide plus bifocal spectacles vs SVLs · children with myopia (nearsightedness)
1 finding from 1 review