Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

411 questions · 420 findings · 42 reviews

No studies found 99 · 23.6%GRADE not reported 35 · 8.3%Very low 135 · 32.1%Low 114 · 27.1%Moderate 34 · 8.1%High 3 · 0.7%

Probiotics vs other active intervention

Grade ≥ 3 diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics may leads to lower severity of diarrhoea: grade 3 or higher compared with other active treatment (low certainty).

1 finding from 1 review

Probiotics vs other active intervention

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

It is very uncertain whether probiotics changes requiring rescue medication for diarrhoea compared with other active treatment (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Median (mean) time to use of rescue medication · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics showed no clear difference in requiring rescue medication for diarrhoea compared with placebo (moderate certainty).

2 findings from 1 review

Probiotics vs placebo

Adverse events · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

All‐cause mortality · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review