Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

141 questions · 153 findings · 16 reviews · Urology

No studies found 42 · 27.5%GRADE not reported 2 · 1.3%Very low 16 · 10.5%Low 56 · 36.6%Moderate 33 · 21.6%High 4 · 2.6%

Pazopanib vs placebo (targeted agent versus placebo)

Progression‐free survival · Previous treated and treatment‐naïve (54%) metastatic renal cell carcinoma (clear cell type)

Pazopanib leads to lower progression‐free survival (absolute effect size estimates based on… compared with placebo (targeted agent versus placebo) (high certainty).

1 finding from 1 review

Pazopanib vs placebo (targeted agent versus placebo)

Overall survival (absolute effect size estimates based on survival rate at 24 months) · Previous treated and treatment‐naïve (54%) metastatic renal cell carcinoma (clear cell type)

Pazopanib showed no clear difference in overall survival (absolute effect size estimates based on survival… compared with placebo (targeted agent versus placebo) (low certainty).

1 finding from 1 review