Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

263 questions · 269 findings · 34 reviews

No studies found 64 · 23.8%GRADE not reported 23 · 8.6%Very low 32 · 11.9%Low 77 · 28.6%Moderate 55 · 20.4%High 18 · 6.7%

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 30 days · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab leads to lower development of clinical COVID‐19 symptoms within 30 days compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review