What do systematic reviews say?

Antidepressants vs mood stabilisers

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 58 participants
  Very low

Antidepressants vs mood stabilisers

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 58 participants
  Very low

Antidepressants vs mood stabilisers

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs mood stabilisers

It is very uncertain whether antidepressants changes responder status compared with mood stabilisers (very low certainty).

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  RR 0.63 [0.29, 1.33]
  1 study · 31 participants
  Very low

Opioid antagonists vs mood stabilisers

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 90 participants
  Low

Opioid antagonists vs mood stabilisers

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioid antagonists vs mood stabilisers

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioid antagonists vs mood stabilisers

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioid antagonists vs mood stabilisers

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Very low

Opioid antagonists vs mood stabilisers

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Very low

Opioid antagonists vs mood stabilisers

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioid antagonists vs mood stabilisers

The review found no eligible studies for this question.

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 41 participants
  Very low

Antidepressants vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 110 participants
  Low

Antidepressants vs placebo

It is very uncertain whether antidepressants changes responder status compared with placebo (very low certainty).

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  RR 1.24 [0.93, 1.66]
  6 studies · 268 participants
  Very low

Opioid antagonists vs placebo

• Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 259 participants
  Low

Switching to mianserin (60 mg/d) vs continuing on current antidepressant (fluoxetine 20 mg/d)

Switching to mianserin (60 mg/d) showed no clear difference in depressive symptoms (HAM‐D) Scale from: 0 to 54 (worse) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 71 participants
  Low

Augmentation of current antidepressant (fluoxetine 20 mg/d) with mianserin (60 mg/d) vs placebo plus antidepressant

The review found no eligible studies for this question.

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Augmentation of current antidepressant (SSRI/SNRI) with mirtazapine (30 mg/d) vs augmentation of current antidepressant (various) with placebo

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 431 participants
  High