Findings

What do systematic reviews say?

94 questions · 100 findings · 31 reviews · Airways

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No studies found 9 · 9%GRADE not reported 11 · 11%Very low 22 · 22%Low 30 · 30%Moderate 24 · 24%High 4 · 4%

Children: higher dose/longer course vs lower dose/shorter course

FEV1 % predicted · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
GRADE not reported

Children: higher dose/longer course vs lower dose/shorter course

All adverse events · children with acute asthma

Children: higher dose/longer course showed no clear difference in all adverse events compared with lower dose/shorter course (moderate certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.67 [0.11, 4.08]
1 study · 201 participants
Moderate

Children: prednisolone vs dexamethasone

Admission to hospital at initial presentation · children with acute asthma

Children: prednisolone showed no clear difference in admission at initial presentation compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.08 [0.74, 1.58]
3 studies · 1007 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Asthma severity and symptoms · Adults with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Children: prednisolone vs dexamethasone

Re‐admission during · children with acute asthma

Children: prednisolone showed no clear difference in re‐admission during compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.44 [0.15, 1.33]
3 studies · 985 participants
Low

Children: prednisolone vs dexamethasone

Asthma symptoms · children with acute asthma

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 328 participants
Very low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 533 participants
GRADE not reported

Children: prednisolone vs dexamethasone

Serious adverse events · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 255 participants
GRADE not reported

Children: prednisolone vs dexamethasone

Exacerbations · children with acute asthma

Children: prednisolone showed no clear difference in new exacerbation during compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.85 [0.54, 1.34]
4 studies · 981 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Asthma symptoms Complete resolution by day 28 · Adults with acute asthma

Adults: higher dose/longer course showed no clear difference in asthma symptoms Complete resolution by day 28 compared with lower dose/shorter course (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.55 [0.13, 2.26]
1 study · 35 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Exacerbations · Adults with acute asthma

It is very uncertain whether adults: higher dose/longer course changes new exacerbation in compared with lower dose/shorter course (very low certainty).

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.98 [0.17, 5.56]
2 studies · 55 participants
Very low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.62 [0.23, 1.68]
3 studies · 122 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

FEV1 % predicted · Adults with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 41 participants
Very low

Adults: higher dose/longer course vs lower dose/shorter course

All adverse events · Adults with acute asthma

It is very uncertain whether adults: higher dose/longer course changes all adverse events compared with lower dose/shorter course (very low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 4.15 [0.94, 18.41]
1 study · 43 participants
Very low

Adults: prednisolone vs dexamethasone

Re‐admission during · Adults with acute asthma

It is very uncertain whether adults: prednisolone changes re‐admission during compared with dexamethasone (very low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.35 [0.04, 3.47]
1 study · 200 participants
Very low

Adults: prednisolone vs dexamethasone

Asthma symptoms Returned to normal activities within 3 days · Adults with acute asthma

Adults: prednisolone showed no clear difference in asthma symptoms Returned to normal activities within 3 days compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.44 [0.19, 1.01]
1 study · 191 participants
Low