Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

100 questions · 100 findings · 9 reviews · Musculoskeletal

No studies found 24 · 24%GRADE not reported 2 · 2%Very low 12 · 12%Low 34 · 34%Moderate 23 · 23%High 5 · 5%

Celecoxib vs tNSAIDs

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Number experiencing gastro‐intestinal events (perforation, ulcer, bleeds) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing gastro‐intestinal events (perforation, ulcer,… compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs tNSAIDs

Cardiovascular events (myocardial infarction, stroke) · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing cardiovascular events (myocardial infarction,… compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Cardiovascular events (myocardial infarction, stroke) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in cardiovascular events (myocardial infarction, stroke) compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Incidence of gastroduodenal ulcers ≥ 3 mm · patients with rheumatoid arthritis

Celecoxib probably leads to lower incidence of gastroduodenal ulcers ≥ 3 mm compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with traditional NSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Total number of withdrawals · patients with rheumatoid arthritis

Celecoxib probably leads to lower total withdrawals; compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Pain A 0 t o 100 visual or numerical scale, where 0 equals no pain at all and 100 is the worst pain imaginable · patients with rheumatoid arthritis
1 finding from 1 review

NSAID injection vs glucocorticoid injection

Resolution at 12 to 24 weeks Quinell Grade (range 0 to 4, resolved disease is grade 0) · adults (> 18 years of age) with trigger finger

NSAID injection showed no clear difference in resolution at 12 to 24 weeks Quinell Grade (range 0 to 4, resolved… compared with glucocorticoid injection (low certainty).

1 finding from 1 review