Celecoxib vs tNSAIDs
Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).
- Peto OR 0.97 [0.74, 1.27]8 studies · 3150 participantsLow
Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).
It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).
It is very uncertain whether celecoxib changes number experiencing gastro‐intestinal events (perforation, ulcer,… compared with tNSAIDs (very low certainty).
It is very uncertain whether celecoxib changes number experiencing cardiovascular events (myocardial infarction,… compared with tNSAIDs (very low certainty).
Celecoxib showed no clear difference in cardiovascular events (myocardial infarction, stroke) compared with traditional NSAIDs (low certainty).
Celecoxib probably leads to lower incidence of gastroduodenal ulcers ≥ 3 mm compared with traditional NSAIDs (moderate certainty).
Celecoxib showed no clear difference in short‐term serious adverse events compared with traditional NSAIDs (low certainty).
Celecoxib probably leads to lower total withdrawals; compared with traditional NSAIDs (moderate certainty).
Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).
NSAID injection showed no clear difference in resolution at 12 to 24 weeks Quinell Grade (range 0 to 4, resolved… compared with glucocorticoid injection (low certainty).
NSAID injection may leads to higher persistent moderate to severe symptoms at 12 to 24 weeks compared with glucocorticoid injection (low certainty).
It is very uncertain whether NSAID injection changes recurrence at 12 to 24 weeks compared with glucocorticoid injection (very low certainty).
NSAID injection showed no clear difference in residual pain compared with glucocorticoid injection (low certainty).
NSAID injection showed no clear difference in participant‐reported treatment success compared with glucocorticoid injection (low certainty).
It is very uncertain whether NSAID injection changes adverse events compared with glucocorticoid injection (very low certainty).