Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

476 questions · 488 findings · 43 reviews

No studies found 134 · 27.5%GRADE not reported 21 · 4.3%Very low 91 · 18.6%Low 135 · 27.7%Moderate 78 · 16%High 29 · 5.9%

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Secondary outcome: acceptability of treatment · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

> 50% reduction in depressive symptoms · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes proportions of participants responding to treatment ≥ 50% reduction… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review