Findings

What do systematic reviews say?

99 questions · 105 findings · 7 reviews · Fertility Regulation

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No studies found 38 · 36.2%GRADE not reported 0 · 0%Very low 15 · 14.3%Low 36 · 34.3%Moderate 14 · 13.3%High 2 · 1.9%

Sublingual misoprostol vs vaginal misoprostol

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Mifepristone alone vs mifepristone (200 mg) plus prostaglandin

Failure to achieve complete abortion · women undergoing first trimester abortion

It is very uncertain whether mifepristone alone changes failure to achieve complete abortion compared with mifepristone/prostaglandin (very low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 3.25 [0.81, 13.09]
3 studies · 273 participants
Very low

Mifepristone alone vs mifepristone (200 mg) plus prostaglandin

Nausea · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Mifepristone alone vs mifepristone (200 mg) plus prostaglandin

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Mifepristone alone vs mifepristone (200 mg) plus prostaglandin

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prostaglandin vs combined regimen

Failure to achieve complete abortion · women undergoing first trimester abortion

Prostaglandin alone may leads to higher failure to achieve complete abortion compared with combined regimen (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 2.39 [1.89, 3.02]
18 studies · 3471 participants
Low

Mifepristone (600 mg) plus prostaglandin vs mifepristone (200 mg) plus prostaglandin

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prostaglandin vs combined regimen

Nausea · women undergoing first trimester abortion

Prostaglandin alone showed no clear difference in nausea compared with combined regimen (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.9 [0.74, 1.1]
12 studies · 2722 participants
Low

Prostaglandin vs combined regimen

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Prostaglandin alone showed no clear difference in women's dissatisfaction with the procedure compared with combined regimen (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.65 [0.75, 3.64]
5 studies · 1485 participants
Low

Prostaglandin vs combined regimen

Blood transfusion · women undergoing first trimester abortion

Prostaglandin alone showed no clear difference in blood transfusion compared with combined regimen (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.33 [0.03, 3.13]
1 study · 300 participants
Low

Sublingual misoprostol vs vaginal misoprostol

Failure to achieve complete abortion · first trimester abortion

Sublingual misoprostol alone showed no clear difference in failure to achieve complete abortion compared with vaginal misoprostol alone (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.69 [0.37, 1.28]
5 studies · 2705 participants
Low

Sublingual misoprostol vs vaginal misoprostol

Nausea · first trimester abortion

Sublingual misoprostol alone showed no clear difference in nausea compared with vaginal misoprostol alone (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.61 [0.78, 3.33]
4 studies · 2505 participants
Low

Sublingual misoprostol vs vaginal misoprostol

Women's dissatisfaction with the procedure · first trimester abortion

Sublingual misoprostol alone may leads to lower women's dissatisfaction with the procedure compared with vaginal misoprostol alone (low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.14 [0.07, 0.29]
1 study · 220 participants
Low

Mifepristone (600 mg) plus prostaglandin vs mifepristone (200 mg) plus prostaglandin

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sublingual misoprostol vs vaginal misoprostol

Blood transfusion · first trimester abortion

It is very uncertain whether sublingual misoprostol alone changes blood transfusion compared with vaginal misoprostol alone (very low certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 5 [0.24, 102.96]
1 study · 220 participants
Very low

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Failure to achieve complete abortion · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg probably leads to lower failure to achieve complete abortion compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.63 [0.51, 0.78]
3 studies · 4424 participants
Moderate

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Nausea · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg showed no clear difference in nausea compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.99 [0.94, 1.05]
3 studies · 4424 participants
Moderate

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg probably leads to lower women's dissatisfaction with the procedure compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 0.75 [0.6, 0.93]
3 studies · 4420 participants
Moderate

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

1 finding from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found