Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

120 questions · 126 findings · 6 reviews · Endodontics and dental trauma

No studies found 21 · 16.7%GRADE not reported 78 · 61.9%Very low 16 · 12.7%Low 11 · 8.7%Moderate 0 · 0%High 0 · 0%

Guided tissue regeneration (GTR) with bovine bone mineral + resorbable collagen membrane vs No GTR (no grafting)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Guided tissue regeneration (GTR) with bovine bone mineral +… showed no clear difference in healing - 1 year compared with no GTR (no grafting) (low certainty).

1 finding from 1 review

Placebo (sham irradiation, laser inactive) vs Control (no laser device used)

Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)

Placebo (sham irradiation, laser inactive) led to lower maximum pain (verbal rating scale, VRS) compared with control (no laser device used); GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in postoperative pain (VAS 0-100) - 1 day compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

1 finding from 1 review

Intermediate restorative material (IRM) root-end filling vs Gutta-percha

Healing - 1 year or longer · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether intermediate restorative material (IRM) root-end filling changes healing - 1 year or longer compared with gutta-percha (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling may leads to higher healing - 1 year compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in healing - 1 year compared with intermediate restorative material (IRM) (low certainty).

1 finding from 1 review

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Resin composite restoration

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; both arms had 16% failure.

1 finding from 1 review

Bulk-fill composite resin with 15-second dentine etching vs Bulk-fill composite resin with 7-second dentine etching

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; the 7-second etching arm had a lower tabulated failure rate.

1 finding from 1 review

HVGIC Fuji IX Gold Label vs HVGIC Vitro Molar and Maxxion R

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; failure rates were tabulated.

1 finding from 1 review

Conventional GIC vs Compomer and glass carbomer

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; cumulative failure was highest for glass carbomer.

1 finding from 1 review

High-viscosity glass-ionomer cement (HVGIC) restoration (conventional restorative approach) vs Resin composite restoration

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; composite resin outperformed HVGIC in the review narrative.

1 finding from 1 review