Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,133 questions · 1,153 findings · 36 reviews · Skin

No studies found 407 · 35.3%GRADE not reported 90 · 7.8%Very low 183 · 15.9%Low 209 · 18.1%Moderate 211 · 18.3%High 53 · 4.6%

Topical aciclovir (short‐term) vs placebo

Severity (aborted lesions) of attack of recurrent herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in severity (aborted lesions) of attack of recurrent herpes labialis… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) may leads to lower incidence of herpes labialis after use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir and 348U87 cream (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether topical aciclovir and 348U87 cream (short‐term) changes incidence of herpes labialis during use of the preventative… compared with placebo (very low certainty).

2 findings from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention (by culture) ‐ aciclovir 400 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) may leads to lower incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Topical foscarnet vs placebo

Adverse effects during use of the preventative intervention (leading to discontinuation) · participants with recurrent herpes labialis

Topical foscarnet showed no clear difference in adverse effects during use of the preventative intervention (leading… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 800 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (moderate certainty).

1 finding from 1 review

Sunscreen vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether sunscreen changes incidence of herpes labialis during use of the preventative… compared with placebo (very low certainty).

2 findings from 1 review