Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

315 questions · 326 findings · 28 reviews

No studies found 78 · 23.9%GRADE not reported 15 · 4.6%Very low 77 · 23.6%Low 76 · 23.3%Moderate 65 · 19.9%High 15 · 4.6%

IVIg vs prednisolone

Incidence of CAAs (acute phase) · people undergoing initial treatment for KD

It is very uncertain whether primary treatment with intravenous immunoglobulin (IVIG) changes incidence of CAAs (acute phase) compared with prednisolone (very low certainty).

1 finding from 1 review

IVIg vs prednisolone

Incidence of any adverse effects after treatment initiation ( · people undergoing initial treatment for KD

Primary treatment with intravenous immunoglobulin (IVIG) showed no clear difference in incidence of any adverse effects after treatment initiation (up to 3… compared with prednisolone (low certainty).

1 finding from 1 review

IVIg vs acetylsalicylic acid (ASA)

Incidence of any adverse effects after treatment initiation ( · people undergoing initial treatment for KD

It is very uncertain whether primary treatment with intravenous immunoglobulin (IVIG) changes incidence of any adverse effects after treatment initiation (from 30… compared with acetylsalicylic acid (ASA) (very low certainty).

1 finding from 1 review

IVIg vs different infusion regimens of IVIG

Incidence of any adverse effects after treatment initiation ( · people undergoing initial treatment for KD

Primary treatment with intravenous immunoglobulin (IVIG) showed no clear difference in incidence of any adverse effects after treatment initiation ( compared with different infusion regimens of IVIG (low certainty).

1 finding from 1 review

Intravenous immunoglobulin with or without standard care vs placebo or usual care

Significant disability assessed using Liverpool Outcome Score RR (M‐H, random‐effects analysis, 95% CI) · children with acute encephalitis

It is very uncertain whether intravenous immunoglobulin with or without standard care changes significant disability assessed using Liverpool Outcome Score RR… compared with standard care alone or placebo (very low certainty).

1 finding from 1 review

Intravenous immunoglobulin with or without standard care vs placebo or usual care

Serious adverse events Analysis 11.2 · children with acute encephalitis

It is very uncertain whether intravenous immunoglobulin with or without standard care changes ≥ 1 serious adverse event RR (M‐H, random‐effects analysis, 95% CI) compared with standard care alone or placebo (very low certainty).

1 finding from 1 review