Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

391 questions · 443 findings · 71 reviews

No studies found 54 · 12.2%GRADE not reported 105 · 23.7%Very low 125 · 28.2%Low 103 · 23.3%Moderate 40 · 9%High 16 · 3.6%

Analogue (conventional) radiographs vs Digital radiographs (direct within-person / paired comparison); reference standard: histology, excavation, or enhanced visual examination

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
2 findings from 1 review

Analogue (conventional) radiographs vs Reference standard (histology, excavation, or enhanced visual examination)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Cone beam computed tomography (CBCT) vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
3 findings from 1 review

Cone beam computed tomography (CBCT) vs Digital radiographs (direct within-person / paired comparison); reference standard: histology

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
2 findings from 1 review

Cone beam computed tomography (CBCT) vs Digital radiographs (direct within-person / paired comparison); reference standard: histology

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
2 findings from 1 review

Analogue (conventional) radiographs vs Digital radiographs (direct within-person / paired comparison); reference standard: histology, excavation, or enhanced visual examination

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
2 findings from 1 review

Digital radiographs vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Digital radiographs vs Reference standard (histology, excavation, or enhanced visual examination)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Early treatment vs expectant management

Proportion of infants requiring surgical PDA ligation or transcatheter occlusion · preterm infants

It is very uncertain whether early treatment changes proportion of infants requiring surgical PDA ligation or… compared with expectant management (very low certainty).

1 finding from 1 review

Early treatment vs expectant management

Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants

Early treatment may leads to higher proportion of infants receiving any pharmacotherapy for a… compared with expectant management (low certainty).

1 finding from 1 review

Early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (low certainty).

1 finding from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Functional assessment using a patient reported outcome measure: · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Active finger range of motion · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa
2 findings from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Tendon rupture · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse event (tendon rupture) compared with early controlled passive exercise regimen (very low certainty).

1 finding from 1 review

Summary of findings table 1: comparison of operation types: early results of needle fasciotomy vs limited fasciectomy

DASH hand function score at 3 months Major outcome group 1 (hand function) (scores between 0 and 100, where 0 represents no impairment in hand function and 100 represents maximum impairment in hand function) · 125 hands in 121 participants with Dupuytren's disease of the fingers for early outcomes (van Rijssen 2006)
1 finding from 1 review