Baclofen vs diazepam
AW symptoms (CIWA‐Ar score) · people with alcohol withdrawal
1 finding from 1 review
- no estimate extracted2 studies · 85 participantsVery low
Findings
What do systematic reviews say?
161 questions · 161 findings · 15 reviews · Headline outcomes only
No studies found 65 · 40.4%GRADE not reported 3 · 1.9%Very low 24 · 14.9%Low 31 · 19.3%Moderate 33 · 20.5%High 5 · 3.1%
Baclofen vs diazepam
Global improvement · people with alcohol withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Baclofen vs diazepam
Craving · people with alcohol withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Baclofen vs diazepam
AEs · people with alcohol withdrawal
It is very uncertain whether baclofen changes AEs compared with diazepam (very low certainty).
1 finding from 1 review
- RD 01 study · 37 participantsVery low
Baclofen vs diazepam
Severe AEs · people with alcohol withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Baclofen vs diazepam
Leaving the study early · people with alcohol withdrawal
It is very uncertain whether baclofen changes dropouts compared with diazepam (very low certainty).
1 finding from 1 review
- RD 01 study · 37 participantsVery low
Baclofen vs diazepam
Dropouts due to adverse events · people with alcohol withdrawal
It is very uncertain whether baclofen changes dropouts due to AEs compared with diazepam (very low certainty).
1 finding from 1 review
- RD 01 study · 37 participantsVery low
Benzodiazepines (lorazepam) vs diazepam
Seizure freedom · Children with acute tonic‐clonic seizures
Summary of findings ‐ Lorazepam showed no clear difference in seizure cessation compared with diazepam (low certainty).
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyRR 1.08 [0.98, 1.2]3 studies · 439 participantsLow
Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination
Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyRR 1 [0.98, 1.02]1 study · 178 participantsModerate
Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 178 participantsModerate
Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyRR 0.78 [0.22, 2.82]1 study · 178 participantsModerate
Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination
Additional drugs required to stop the seizure · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous lorazepam showed no clear difference in additional drugs required to stop the seizure compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyRR 0.42 [0.17, 1.04]1 study · 178 participantsModerate
Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 178 participantsModerate
Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination
Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Benzodiazepines (lorazepam) vs diazepam
Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 80 participantsModerate
Summary of findings ‐ Buccal midazolam vs rectal diazepam
Seizure cessation: within 5 minutes to 1 hour · Children with acute tonic‐clonic seizures
It is very uncertain whether summary of findings ‐ Buccal midazolam changes seizure cessation: within 5 minutes to 1 hour compared with rectal diazepam (very low certainty).
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyRR 1.25 [1.13, 1.38]4 studies · 648 participantsVery low
Summary of findings ‐ Buccal midazolam vs rectal diazepam
Time from drug administration to of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 141 participantsLow
Summary of findings ‐ Buccal midazolam vs rectal diazepam
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
Summary of findings ‐ Buccal midazolam showed no clear difference in incidence of respiratory depression compared with rectal diazepam (low certainty).
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyRR 0.88 [0.61, 1.25]4 studies · 648 participantsLow
Summary of findings ‐ Buccal midazolam vs rectal diazepam
Additional drugs required to stop the seizure: intravenous lorazepam required · Children with acute tonic‐clonic seizures
Summary of findings ‐ Buccal midazolam may leads to lower additional drugs required to stop the seizure: intravenous lorazepam… compared with rectal diazepam (low certainty).
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyRR 0.58 [0.42, 0.79]1 study · 177 participantsLow
Summary of findings ‐ Buccal midazolam vs rectal diazepam
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found