Findings

What do systematic reviews say?

90 questions · 90 findings · 23 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 39 · 43.3%GRADE not reported 0 · 0%Very low 22 · 24.4%Low 22 · 24.4%Moderate 5 · 5.6%High 2 · 2.2%

Intervention not reported

Number of days on antibiotics for acute exacerbations · infants and young children with cystic fibrosis

The intervention showed no clear difference in number of days on antibiotics for acute exacerbations (moderate certainty).

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Moderate

Intervention not reported

Change in total calories (Kcal/day): at 12 months · adults and children with cystic fibrosis

1 finding from 1 review

Oral calorie supplements for cystic fibrosis 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 58 participants
Low

Intervention not reported

Change in total protein (g/day): at 12 months · adults and children with cystic fibrosis

1 finding from 1 review

Oral calorie supplements for cystic fibrosis 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 58 participants
Low

Intervention not reported

Change in total fat (g/day): at 12 months · adults and children with cystic fibrosis

1 finding from 1 review

Oral calorie supplements for cystic fibrosis 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 58 participants
Low

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in total calories (Kcal/day): at 12 months · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 53 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in total protein intake (g/day) at 3 months · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 53 participants
High

Dornase alfa vs alternate days

Mean relative percentage in quality of life score at 3 months · children with cystic fibrosis

Dornase alfa daily showed no clear difference in mean relative percentage in quality of life score at 3 months compared with alternate days (low certainty).

1 finding from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 0.01
43 participants
Low

Dornase alfa vs alternate days

Pulmonary exacerbations · children with cystic fibrosis

1 finding from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
43 participants
Low

Dornase alfa vs alternate days

FEV1 · children with cystic fibrosis

Dornase alfa daily showed no clear difference in mean relative percentage change in FEV1 (L) at 3 months compared with alternate days (low certainty).

1 finding from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 2
43 participants
Low

Dornase alfa vs alternate days

Mean relative percentage in FVC (L) at 3 months · children with cystic fibrosis

Dornase alfa daily showed no clear difference in mean relative percentage in FVC (L) at 3 months compared with alternate days (low certainty).

1 finding from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 0.03
43 participants
Low