Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 93 findings · 12 reviews · Schizophrenia

No studies found 15 · 16.1%GRADE not reported 11 · 11.8%Very low 43 · 46.2%Low 12 · 12.9%Moderate 12 · 12.9%High 0 · 0%

HALOPERIDOL vs chlorpromazine

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ cardiovascular ‐ hypotension compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse effects: specific ‐ seizure · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ central nervous system ‐ seizures compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

Intervention not reported

Service utilisation: hospital admission (short term) · patients with schizophrenia

The intervention showed no clear difference in service utilisation: hospital admission (short term) (low certainty).

1 finding from 1 review

Intervention not reported

Global state: clinically important change in global state · patients with schizophrenia
1 finding from 1 review

Intervention not reported

Global state: relapse · patients with schizophrenia
1 finding from 1 review

Intervention not reported

Mental state: clinically important change in mental state · patients with schizophrenia
1 finding from 1 review

Intervention not reported

Adverse effect/event: clinically important extrapyramidal adverse events ‐ akathisia (medium term) · patients with schizophrenia

The intervention showed no clear difference in adverse effect/event: clinically important extrapyramidal adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse effect/event: death · patients with schizophrenia
1 finding from 1 review

Intervention not reported

Leaving the study early: any reason (medium term) · patients with schizophrenia

The intervention showed no clear difference in leaving the study early: any reason (medium term) (low certainty).

1 finding from 1 review