What do systematic reviews say?

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower presence of TMJ sounds compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days
  RR 0.59 [0.37, 0.95]
  1 study · 40 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  In the Hegarty 2002 cross-over trial (n=22), no statistical testing of the pain score (VAS 0 to 100) was reported; it is not clear whether the difference is statistically significant (fluticasone mean score 19.8 versus…
  1 study · 22 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No statistical testing of the mean surface area of lesions was reported in Hegarty 2002 (fluticasone mean score 547.2 mm2 versus betamethasone mean score 671.9 mm2).
  1 study · 22 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower pain on palpation of the affected/contralateral TMJ and masticatory… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  Pain on palpation of the affected and contralateral TMJ and masticatory muscles presented similar frequencies regardless of the time (Analyses 1.4-1.12); no statistically significant differences reported. Point…
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
  1 study · 40 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  Table 3 (Side-effects). Hegarty 2002: nausea (4), swollen mouth (1), bad taste and smell (6), difficulty in spray application (7), dry mouth (2), sore throat (1), red painful tongue (1), and pseudomembranous…
  1 study · 44 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower reported pain (mm on VAS) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  6 months
  MD -17.00 [-32.60, -1.40]
  1 study · 40 participants
  GRADE not reported

Human placental extract vs Disprin (aspirin/betamethasone)

Human placental extract led to higher improvement in mucositis compared with disprin (aspirin/betamethasone); GRADE not reported.

• Interventions for treating oral mucositis for patients with cancer receiving treatment 2010 · Cochrane All outcomes
  RR 4.50 [2.29, 8.86]
  1 study · 120 participants
  GRADE not reported