Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

178 questions · 181 findings · 13 reviews

No studies found 33 · 18.2%GRADE not reported 13 · 7.2%Very low 46 · 25.4%Low 37 · 20.4%Moderate 42 · 23.2%High 10 · 5.5%

FLUPHENAZINE (ORAL) vs AMISULPRIDE

Adverse effects: Extrapyramidal effects ‐ concomitant anticholinergic medication ‐ short term (up to 12 weeks) Participants requiring concomitant anticholinergic medication · patients with schizophrenia

It is very uncertain whether FLUPHENAZINE (ORAL) changes adverse effects: Extrapyramidal effects ‐ concomitant… compared with AMISULPRIDE (very low certainty).

1 finding from 1 review

FLUPHENAZINE (ORAL) vs RISPERIDONE

Clinically important response (defined by study) ‐ short term (up to 12 weeks) decreased rate of BPRS score < 20% · patients with schizophrenia

It is very uncertain whether FLUPHENAZINE (ORAL) changes clinically important response (defined by study) ‐ short term (up to… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs RISPERIDONE

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

COMPARISON 3. ARIPIPRAZOLE showed no clear difference in global state: No clinically significant response (as defined by the… compared with RISPERIDONE (low certainty).

1 finding from 1 review