Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

177 questions · 179 findings · 10 reviews · Schizophrenia

No studies found 33 · 18.4%GRADE not reported 13 · 7.3%Very low 54 · 30.2%Low 39 · 21.8%Moderate 31 · 17.3%High 9 · 5%

FLUPHENAZINE (ORAL) vs AMISULPRIDE

Adverse effects: Extrapyramidal effects ‐ concomitant anticholinergic medication ‐ short term (up to 12 weeks) Participants requiring concomitant anticholinergic medication · patients with schizophrenia

It is very uncertain whether FLUPHENAZINE (ORAL) changes adverse effects: Extrapyramidal effects ‐ concomitant… compared with AMISULPRIDE (very low certainty).

1 finding from 1 review

FLUPHENAZINE (ORAL) vs RISPERIDONE

Clinically important response (defined by study) ‐ short term (up to 12 weeks) decreased rate of BPRS score < 20% · patients with schizophrenia

It is very uncertain whether FLUPHENAZINE (ORAL) changes clinically important response (defined by study) ‐ short term (up to… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs RISPERIDONE

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

COMPARISON 3. ARIPIPRAZOLE showed no clear difference in global state: No clinically significant response (as defined by the… compared with RISPERIDONE (low certainty).

1 finding from 1 review