Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 884 findings · 229 reviews · Headline outcomes only

No studies found 136 · 15.4%GRADE not reported 37 · 4.2%Very low 242 · 27.4%Low 298 · 33.7%Moderate 131 · 14.8%High 40 · 4.5%

Summary of findings. Peer reviewer training vs standard journal practice or no training

Stakeholders' assessment of review quality (change score) Assessed using either:A) a 5‐point scale, change scores range from −4 to 4 (3 studies);B) a 5‐point scale, expressed by "slope of quality score change"(1 study); orC) the MQAI, from −144 to... · peer reviewers
1 finding from 1 review

Methylnaltrexone vs placebo

Laxation response: patient assessment of change in bowel status at the end of trial · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction

Methylnaltrexone may leads to higher laxation response: patient assessment of change in bowel statusgat… compared with placebo (low certainty).

1 finding from 1 review

Naldemedine vs placebo

Laxation response: patient assessment of change in bowel status at the end of trial · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Lower‐dose methylnaltrexone vs higher dose

Laxation response: patient assessment of change in bowel status at the end of trial · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction

Methylnaltrexone lower dose showed no clear difference in laxation response: patient assessment of change in bowel statusgat… compared with higher dose (low certainty).

1 finding from 1 review

Low dose naldemedine vs higher dose

Laxation response: patient assessment of change in bowel status at the end of trial · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Joint crisis plan plus treatment as usual vs treatment

Deatha Timing of outcome assessment: 12 months · community‐dwelling adults with a diagnosis of borderline personality disorder

Joint crisis plan plus treatment as usual showed no clear difference in deatha Timing of outcome assessment: 6 months compared with treatment (low certainty).

1 finding from 1 review

Brief admission to psychiatric hospital by self‐referral plus treatment as usual vs treatment

Violence perpetration · adults meeting 3 or more diagnostic criteria for borderline personality disorder

Brief admission to psychiatric hospital by self‐referral plus… showed no clear difference in violence perpetration: number of participants who perpetrated… compared with treatment (low certainty).

1 finding from 1 review