Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

158 questions · 167 findings · 20 reviews · Headline outcomes only

No studies found 40 · 24%GRADE not reported 14 · 8.4%Very low 45 · 26.9%Low 33 · 19.8%Moderate 30 · 18%High 5 · 3%

Aspirin vs vitamin K antagonist (VKA)

Major bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes major bleeding compared with vitamin K antagonist (VKA) (very low certainty).

2 findings from 1 review

Aspirin plus antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Global state: any change in global state – unspecified problem necessitating change in dose or type of antipsychotics – medium term · patients with schizophrenia

It is very uncertain whether aspirin plus antipsychotics changes global state: any change in global state – unspecified problem… compared with placebo plus antipsychotics (very low certainty).

1 finding from 1 review

Aspirin plus antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

It is very uncertain whether aspirin plus antipsychotics changes leaving the study early: short‐term – for any reason compared with placebo plus antipsychotics (very low certainty).

1 finding from 1 review

Aspirin plus antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Adverse events: gastrointestinal – dyspeptic symptoms – self‐assessed as at least 'moderate' · patients with schizophrenia

It is very uncertain whether aspirin plus antipsychotics changes adverse events: gastrointestinal – dyspeptic symptoms –… compared with placebo plus antipsychotics (very low certainty).

1 finding from 1 review

Aspirin plus antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Service use: change in hospital status – any change · patients with schizophrenia

It is very uncertain whether aspirin plus antipsychotics changes service use: change in hospital status – any change compared with placebo plus antipsychotics (very low certainty).

1 finding from 1 review

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) vs placebo or active comparators (paracetamol, tranexamic acid)

Menstrual blood loss: mean loss

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) showed no clear difference in menstrual blood loss (alkaline hematin method) compared with placebo or active comparators (paracetamol, tranexamic acid); GRADE not reported.

2 findings from 1 review

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) vs placebo or active comparators (paracetamol, tranexamic acid)

Duration of bleeding (menstrual diary)

Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) showed no clear difference in duration of bleeding (menstrual diary) compared with placebo or active comparators (paracetamol, tranexamic acid); GRADE not reported.

1 finding from 1 review