Staining · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Signs of acute toxicity during gel application (nausea, gagging, vomiting) · Children and adolescents aged 16 years or less
It is very uncertain whether fluoride gel (topically applied; operator- or self-applied; any… changes signs of acute toxicity during gel application (nausea, gagging,… compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Proportion developing new caries · Children and adolescents aged 16 years or younger (permanent dentition)
Fluoride gel (topically applied; operator- or self-applied; any… led to lower proportion of children developing new caries compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Caries increment in primary/deciduous teeth: decayed, (extraction indicated/missing) and filled teeth d(e/m)ft (prevented fraction) · Children with primary (deciduous) teeth (younger children)
The review found no eligible studies for this question.
1 finding from 1 review
Proportion of children not remaining caries-free · Children and adolescents aged 16 years or younger (permanent dentition)
Fluoride gel (topically applied; operator- or self-applied; any… showed no clear difference in proportion of children not remaining caries-free compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Dental caries: dmfs increment (primary teeth) · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Proportion developing new caries · Children and adolescents aged 16 years or less
Fluoride mouthrinse (any fluoride agent, concentration, volume,… showed no clear difference in proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less
1 finding from 1 review
One trial (Rugg-Gunn 1973) reported incompletely on oral soft tissue irritation/signs of sensitivity (allergic reaction): "no cases of mucosal hypersensitivity after periodical examinations of every subject". 434…
1 study · 434 participants
Very low
Signs of acute toxicity during gel application (nausea, gagging, vomiting) · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
It is very uncertain whether fluoride mouthrinse (any fluoride agent, concentration, volume,… changes unacceptability of treatment as measured by leaving study early… compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less
1 finding from 1 review
Proportion of children not remaining caries-free · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Tooth staining/discolouration (adverse effect) · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
Show 4 more findings
PF 0.28 [0.19, 0.37]
22 studies
GRADE not reported
PF 0.40 [0.31, 0.49]
17 studies
GRADE not reported
PF 0.24 [0.21, 0.28]
70 studies
GRADE not reported
PF 0.46 [0.30, 0.63]
7 studies
GRADE not reported
Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
PF 0.26 [0.21, 0.30]
79 studies
GRADE not reported
PF 0.53 [0.23, 0.82]
3 studies
GRADE not reported
PF 0.32 [0.19, 0.46]
10 studies
GRADE not reported
Show 4 more findings
PF 0.45 [0.32, 0.58]
7 studies
GRADE not reported
PF 0.24 [0.18, 0.30]
13 studies
GRADE not reported
PF 0.24 [0.20, 0.28]
72 studies
GRADE not reported
PF 0.23 [0.19, 0.28]
53 studies
GRADE not reported
Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less
1 finding from 1 review
Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
Studies not reported
GRADE not reported
Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
RR 1.20 [0.85, 1.70]
10 studies
GRADE not reported
Proportion developing new caries · Children and adolescents aged 16 years or younger (permanent dentition)
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… led to lower proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
RR 0.88 [0.82, 0.95]
13 studies
GRADE not reported