Response (≥ 50% reduction in MADRS or HAM‐D score) ‐ Any dose · treatment‐resistant depression in adults
Augmentation of current antidepressant (SSRI) with ziprasidone (40… probably leads to higher response (≥ 50% reduction in MADRS/HAM‐D score) ‐ Any dose compared with augmentation of current antidepressant (SSRI) with placebo or… (moderate certainty).
1 finding from 1 review
Remission (HAM‐D total score ≤ 8) · treatment‐resistant depression in adults
Switching to mianserin (60 mg/d) showed no clear difference in remission (HAM‐D total score ≤ 8) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).
1 finding from 1 review
Remission · treatment‐resistant depression in adults
Augmentation of current antidepressant (SSRI) with ziprasidone (40… showed no clear difference in remission (clinician‐rated) ‐ Any dose compared with augmentation of current antidepressant (SSRI) with placebo or… (moderate certainty).
1 finding from 1 review
Quality of life ‐ not measured · treatment‐resistant depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not measured · treatment‐resistant depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depressive symptoms · treatment‐resistant depression in adults
1 finding from 1 review
Leaving the study early · treatment‐resistant depression in adults
Augmentation of current antidepressant (fluoxetine 20 mg/d) with… showed no clear difference in dropouts compared with augmentation of current antidepressant (fluoxetine 20 mg/d) with… (low certainty).
1 finding from 1 review
Proportions of participants responding to treatment ≥ 50% reduction in depression score from baseline to end of treatment. A larger RR indicates greater response to treatment in the SAMe group · treatment‐resistant depression in adults
Augmentation of current antidepressant (fluoxetine 20 mg/d) with… may leads to higher response (≥ 50% reduction in HAM‐D score) compared with augmentation of current antidepressant (fluoxetine 20 mg/d) with… (low certainty).
1 finding from 1 review
Remission · treatment‐resistant depression in adults
Augmentation of current antidepressant (fluoxetine 20 mg/d) with… may leads to higher remission (HAM‐D total score ≤ 7) compared with augmentation of current antidepressant (fluoxetine 20 mg/d) with… (low certainty).
1 finding from 1 review
Intervention not reported
Typical antipsychotic vs placebo · critically ill adults with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Typical antipsychotics vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Atypical antipsychotics vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Statin (HMG‐CoA)vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Alpha2 agonist vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Opioid vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Typical antipsychotic vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Atypical antipsychotic vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Statin (HMG‐CoA) vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Alpha2 agonist vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review
Intervention not reported
Cholinesterase inhibitor vs placebo · critically ill adult with confirmed or at high risk of delirium
1 finding from 1 review