Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,747 questions · 3,943 findings · 594 reviews

No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

Adverse effects (wound pain) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Nano-hydroxyapatite (nHA) dentifrice/paste (fluoride-free or fluoridated) vs nHA-free / fluoride-free (negative) control

Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients

Under remineralizing conditions, nHA produced significantly more remineralization than the negative control (MD 350, 95% CI 179 to 521; very low certainty).

2 findings from 1 review

Restricted partial pulpotomy (pulp removal 2-3 mm from exposure site only) vs Extended partial pulpotomy (pulp removal 2-3 mm from entire pulp chamber with complete deroofing)

Overall success (composite of clinical and radiographic success) · Adults (18-45 y) with mature permanent molars, carious exposure and symptomatic irreversible pulpitis

Restricting the lateral extent of partial pulpotomy gives success equivalent to more extensive amputation (97.6% vs 97.5%, p>0.05; ungraded, single trial).

1 finding from 1 review

Restricted partial pulpotomy (pulp removal 2-3 mm from exposure site only) vs Extended partial pulpotomy (pulp removal 2-3 mm from entire pulp chamber with complete deroofing)

Postoperative pain and analgesic intake · Adults (18-45 y) with mature permanent molars, carious exposure and symptomatic irreversible pulpitis

Restricted partial pulpotomy causes less early postoperative pain and analgesic use than extended amputation (p<0.05; ungraded, single trial).

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) and standard urotherapy vs pelvic floor muscle training (PFMT) with electromyographic biofeedback and standard urotherapy

Resolution of daytime urinary incontinence · children aged 5 to 16 years with daytime urinary incontinence

It is very uncertain whether transcutaneous electrical nerve stimulation (TENS) and standard… changes resolution of daytime urinary incontinence compared with pelvic floor muscle training (PFMT) with electromyographic… (very low certainty).

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) and standard urotherapy vs pelvic floor muscle training (PFMT) with electromyographic biofeedback and standard urotherapy

Objective measurement of volume of incontinent episodes · children aged 5 to 16 years with daytime urinary incontinence

The review found no eligible studies for this question.

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) and standard urotherapy vs pelvic floor muscle training (PFMT) with electromyographic biofeedback and standard urotherapy

Resource implications (e.g. cost of incontinence management methods) · children aged 5 to 16 years with daytime urinary incontinence

The review found no eligible studies for this question.

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) and standard urotherapy vs pelvic floor muscle training (PFMT) with electromyographic biofeedback and standard urotherapy

Adverse effects · children aged 5 to 16 years with daytime urinary incontinence

The review found no eligible studies for this question.

1 finding from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Non‐initiation of breastfeeding · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

The review found no eligible studies for this question.

1 finding from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Exclusive breastfeeding at 4‐6 weeks · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

It is very uncertain whether physical breastfeeding support interventions (electric or manual… changes exclusive breastfeeding at 4‐6 weeks compared with usual care (no pump) (very low certainty).

1 finding from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Breastfeeding · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

It is very uncertain whether physical breastfeeding support interventions (electric or manual… changes any breastfeeding at 4‐6 weeks compared with usual care (no pump) (very low certainty).

2 findings from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Exclusive breastfeeding at 6 months · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
Show 2 more findings

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Pain · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review