Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,429 questions · 3,558 findings · 436 reviews

No studies found 660 · 18.5%GRADE not reported 375 · 10.5%Very low 727 · 20.4%Low 887 · 24.9%Moderate 709 · 19.9%High 200 · 5.6%

Individual tailored vs continuous tapered dexamethasone regimen

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

Individual tailored showed no clear difference in death or abnormal neurodevelopmental outcome (various definitions) compared with continuous tapered dexamethasone regimen (low certainty).

1 finding from 1 review

Lower vs higher cumulative dose dexamethasone regimen

Death or cerebral palsy at 1 to 3 years · preterm infants at risk for bronchopulmonary dysplasia

Lower showed no clear difference in death or cerebral palsy at 1 to 3 years compared with higher cumulative dose dexamethasone regimen (low certainty).

1 finding from 1 review

Lower vs higher cumulative dose dexamethasone regimen

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether lower changes death or abnormal neurodevelopmental outcome (various definitions)… compared with higher cumulative dose dexamethasone regimen (very low certainty).

1 finding from 1 review

Later vs earlier initiation of dexamethasone therapy

Death or cerebral palsy at 1 to 3 years · preterm infants at risk for bronchopulmonary dysplasia

Later showed no clear difference in death or cerebral palsy at 1 to 3 years compared with earlier initiation of dexamethasone therapy (low certainty).

1 finding from 1 review

Later vs earlier initiation of dexamethasone therapy

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

Later showed no clear difference in death or abnormal neurodevelopmental outcome (various definitions) compared with earlier initiation of dexamethasone therapy (low certainty).

1 finding from 1 review

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Recurrent PE · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in recurrent PEa compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

All‐cause mortality · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in all‐cause mortality compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

Major bleedinge · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in major bleedinge compared with conventional anticoagulation (low certainty).

1 finding from 1 review

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Recurrent VTEc · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in recurrent VTEc compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

DVTd · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in DVTd compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Major bleedinge · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in major bleedinge compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

Recurrent PE · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in recurrent PEa compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

Recurrent VTEc · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in recurrent VTEc compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral factor Xa inhibitors vs conventional anticoagulation

DVTd · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in DVTd compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review