Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,149 questions · 1,211 findings · 179 reviews

No studies found 175 · 14.5%GRADE not reported 86 · 7.1%Very low 286 · 23.6%Low 341 · 28.2%Moderate 254 · 21%High 69 · 5.7%

Intervention not reported

Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range · adults and children with cystic fibrosis

The intervention showed no clear difference in ototoxicity An increase in auditory threshold of 20 dB or more over… (low certainty).

1 finding from 1 review

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

Diagnosis of PTSD after treatment · various

It is very uncertain whether any early psychological intervention changes PTSD diagnosis: post‐treatment compared with waiting list/usual care (very low certainty).

1 finding from 1 review