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What do systematic reviews say?

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Evidence found and GRADE certainty

1,133 questions · 1,153 findings · 36 reviews · Skin

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No studies found 407 · 35.3%GRADE not reported 90 · 7.8%Very low 183 · 15.9%Low 209 · 18.1%Moderate 211 · 18.3%High 53 · 4.6%

Tetracycline vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review

Tetracycline vs placebo

Time needed until improvement of the skin lesions · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Tetracycline vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline 40 mg vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline 40 mg vs placebo

Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

Duration of remission · Participants with rosacea

Metronidazole probably leads to lower duration of remission compared with placebo (moderate certainty).

1 finding from 1 review

Doxycycline 40 mg vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azithromycin vs doxycycline

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azithromycin vs doxycycline

Participant‐assessed improvement in rosacea severity · Participants with rosacea

It is very uncertain whether azithromycin changes participant‐assessed improvement in rosacea severity compared with doxycycline 100 mg (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

It is very uncertain whether azithromycin changes proportion of participants with adverse event compared with doxycycline 100 mg (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Physician‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azithromycin vs doxycycline

Assessment of erythema or telangiectasia ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review