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What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

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No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Baclofen vs placebo

Frequency of use % of heavy drinking days at the end of treatment · alcohol use disorder
1 finding from 1 review

Baclofen vs placebo

Adverse events: number of participants with ≥ 1 adverse event at end of treatment · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in adverse events: number of participants with ≥ 1 adverse event at end… compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs placebo

Dropout · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in dropouts at end of treatment compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs placebo

Dropouts due to adverse events · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in dropouts due to adverse events compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs acamprosate

Relapse: return to any drinking at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes relapse: return to any drinking at end of treatment compared with acamprosate (very low certainty).

1 finding from 1 review

Baclofen vs acamprosate

Adverse events as N of participants with at least one adverse event subjective and objective · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes adverse events: number of participants with at least one adverse… compared with acamprosate (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of receiving any allogeneic blood product (data only available for intraoperative blood product use) · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Tranexamic acid changes risk of receiving any allogeneic blood product (data only available… compared with placebo (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of reoperation or repeat procedure for bleeding within 7 days · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Tranexamic acid changes risk of reoperation or repeat procedure for bleeding within 7 days compared with placebo (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) · people aged 18 and over undergoing vascular surgery

Summary of findings: Tranexamic acid showed no clear difference in risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Spasticity: number of participants reporting reduction of 30% in the spasticity NRS ( · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher spasticity: number of participants reporting reduction of 30% in the… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Participant‐reported pain relief of 50% or greater · health problem or population

It is very uncertain whether summary of findings table ‐ Cannabis changes pain:number of participants reporting pain relief of 50% or greater… compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Patient Global Impression of Change much or very much improved · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher PGIC:number of participants reporting much or very much improvement… compared with placebo (moderate certainty).

1 finding from 1 review