Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,127 questions · 1,590 findings · 132 reviews · Oral Health

No studies found 189 · 11.9%GRADE not reported 1,166 · 73.3%Very low 130 · 8.2%Low 69 · 4.3%Moderate 25 · 1.6%High 11 · 0.7%

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Rectal cancer · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Rectal cancer: OR 0.50 (95% CI 0.29 to 0.88), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Bone graft with platelet-rich plasma (PRP) vs Bone graft without PRP

Partial graft loss · Patients with insufficient bone below the maxillary sinus requiring dental implants

Bone graft with platelet-rich plasma (PRP) showed no clear difference in partial graft loss compared with bone graft without PRP; GRADE not reported.

1 finding from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected Significant Caries (SiC) index · Alaska Native children (below age 18)

A simulation projected a 50% drop in the Significant Caries index for children (12.3 to 6.1) under the PDHA model (certainty not graded).

2 findings from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected proportion of caries-free children (5-18 years) · Alaska Native children (below age 18)

A simulation projected 0% of children aged 5-18 would be caries-free under the baseline scenario (certainty not graded).

3 findings from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected receipt of school-based prevention services · Alaska Native children (below age 18)

A simulation projected that over 90% of children would receive school-based prevention services under the PDHA model, up from 53% (certainty not graded).

1 finding from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected dental care utilisation · Alaska Native children (below age 18)

A simulation projected that the PDHA program would raise dental care utilisation from 75% to 90% (certainty not graded).

1 finding from 1 review

Brief motivational interviewing (BMI) vs usual treatment alone

Alcohol consumption: consuming more than 21 units of alcohol per week · Male patients aged 16 to 35 years attending an oral and maxillofacial surgery outpatient clinic for follow-up of an alcohol-related facial…

Brief one-session, manual-guided discussion based on the principles… led to lower alcohol consumption: consuming more than 21 units of alcohol per week compared with treatment at the outpatient clinic as usual; GRADE not reported.

1 finding from 1 review

Levamisole 50 mg three times per day for days 1 and 2 vs Levamisole 50 mg three times per day for day 1 and placebo for day 2 (lower dose)

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Recurrence of peri-implantitis · People with at least one dental implant affected by perimplantitis

Er:YAG laser led to lower recurrence of peri-implantitis compared with air-abrasive device (Perio-Flow); GRADE not reported.

1 finding from 1 review

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Er:YAG laser showed no clear difference in change in probing pocket depth compared with air-abrasive device (Perio-Flow); GRADE not reported.

1 finding from 1 review

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Marginal bone level change · People with at least one dental implant affected by perimplantitis

Er:YAG laser showed no clear difference in radiographic marginal bone level change compared with air-abrasive device (Perio-Flow); GRADE not reported.

1 finding from 1 review

Levamisole 50 mg three times per day for days 1 and 2 vs Levamisole 50 mg three times per day for day 1 and placebo for day 2 (lower dose)

Effectiveness · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • A trial at high risk of bias (Zissis 1983) compared two different dose regimens of levamisole (treatment 2 days per week for 16 weeks; a third group received placebo). There was inconsistency in the presentation of the…
    1 study
    GRADE not reported

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Development of TMD (onset/incidence of signs and symptoms) · People without TMD at baseline undergoing orthodontic treatment (TMD clinically absent at baseline); no age restriction provided follow-up…

The review found no eligible studies for this question.

1 finding from 1 review