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What do systematic reviews say?

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Evidence found and GRADE certainty

4,703 questions · 15,007 findings · 1,416 reviews

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No studies found 2,881 · 19.2%GRADE not reported 1,551 · 10.3%Very low 3,111 · 20.7%Low 3,881 · 25.9%Moderate 2,669 · 17.8%High 914 · 6.1%

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Corticosteroids vs placebo

Histological improvement (dichotomous) · inactive EoE patients

Corticosteroids probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Withdrawals due to adverse events · inactive EoE patients

Corticosteroids may leads to lower withdrawals due to adverse events 12 to 50 weeks compared with placebo (low certainty).

1 finding from 1 review

Biologics vs placebo

Clinical improvement (dichotomous) · active EoE patients

Biologics showed no clear difference in clinical improvement (dichotomous) compared with placebo (low certainty).

1 finding from 1 review

Biologics vs placebo

Histological improvement (dichotomous) · active EoE patients

Biologics probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Biologics vs placebo

Withdrawals due to adverse events · active EoE patients

Biologics showed no clear difference in withdrawals due to adverse events 12 to 44 weeks compared with placebo (low certainty).

1 finding from 1 review