Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,261 questions · 1,287 findings · 210 reviews

No studies found 256 · 19.9%GRADE not reported 123 · 9.6%Very low 248 · 19.3%Low 403 · 31.3%Moderate 208 · 16.2%High 49 · 3.8%

Summary of findings table ‐ Phenytoin vs lorazepam

Proportion of infants who develop sedation or drowsiness · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenytoin changes proportion of infants who develop sedation or drowsiness compared with lorazepam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital + bumetanide showed no clear difference in proportion of infants who achieve seizure control after the first… compared with phenobarbital alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes mortality before hospital discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes proportion of infants who develop epilepsy post‐discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Lignocaine vs benzodiazepines

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes proportion of infants who achieve seizure control after maximal… compared with benzodiazepines (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Lignocaine vs benzodiazepines

Mortality or neurodevelopmental disability at 12 months · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes mortality or neurodevelopmental disability at 12 months compared with benzodiazepines (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Proportion of infants with repeat seizure before hospital discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Maintenance ASM changes proportion of infants with repeat seizure before hospital discharge compared with no maintenance ASM after achieving seizure control (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality before hospital discharge · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality before hospital discharge compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality at 18‐24 months · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Need for mechanical ventilation · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes requirement of mechanical ventilation compared with levetiracetam (very low certainty).

1 finding from 1 review