Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,057 questions · 1,077 findings · 32 reviews · Skin

No studies found 395 · 36.7%GRADE not reported 89 · 8.3%Very low 172 · 16%Low 177 · 16.4%Moderate 191 · 17.7%High 53 · 4.9%

Famciclovir vs placebo

Incidence of herpes labialis during use of the preventative intervention (by clinical evaluation) ‐ famciclovir 125 mg · participants with recurrent herpes labialis

Famciclovir showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Famciclovir vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Famciclovir showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

2 findings from 1 review

Famciclovir vs placebo

Duration of attack of recurrent herpes labialis during use of the preventative intervention ‐ famciclovir 125 mg · participants with recurrent herpes labialis

Famciclovir showed no clear difference in duration of attack of recurrent herpes labialis during use of the… compared with placebo (moderate certainty).

1 finding from 1 review

Famciclovir vs placebo

Duration of attack of recurrent herpes labialis during use of the preventative intervention ‐ famciclovir 500 mg · participants with recurrent herpes labialis

Famciclovir probably leads to higher duration of attack of recurrent herpes labialis during use of the… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention (by clinical evaluation) ‐ aciclovir 200 mg 5 times/day · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Severity (aborted lesions) of attack of recurrent herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in severity (aborted lesions) of attack of recurrent herpes labialis… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) may leads to lower incidence of herpes labialis after use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir and 348U87 cream (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether topical aciclovir and 348U87 cream (short‐term) changes incidence of herpes labialis during use of the preventative… compared with placebo (very low certainty).

2 findings from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention (by culture) ‐ aciclovir 400 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) may leads to lower incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Topical foscarnet vs placebo

Adverse effects during use of the preventative intervention (leading to discontinuation) · participants with recurrent herpes labialis

Topical foscarnet showed no clear difference in adverse effects during use of the preventative intervention (leading… compared with placebo (moderate certainty).

1 finding from 1 review