Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,104 questions · 1,200 findings · 23 reviews · Oral medicine and oral cancer

No studies found 143 · 11.9%GRADE not reported 760 · 63.3%Very low 201 · 16.8%Low 66 · 5.5%Moderate 29 · 2.4%High 1 · 0.1%

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) may leads to lower oral mucositis (severe) compared with no treatment (low certainty).

1 finding from 1 review

Oral care protocol vs usual care or no treatment

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Oral care protocol showed no clear difference in oral mucositis (severe) compared with no treatment/usual care; GRADE not reported.

1 finding from 1 review