Findings

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Evidence found and GRADE certainty

1,078 questions · 1,098 findings · 33 reviews · Skin

No studies found 396 · 36.1%GRADE not reported 89 · 8.1%Very low 181 · 16.5%Low 183 · 16.7%Moderate 196 · 17.9%High 53 · 4.8%

Valaciclovir (suppressive regimen vs episodic regimen)

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether valaciclovir (suppressive regimen changes adverse effects during use of the preventative intervention compared with episodic regimen) (very low certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Oral aciclovir (short‐term) may leads to lower incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Famciclovir vs placebo

Incidence of herpes labialis during use of the preventative intervention (by clinical evaluation) ‐ famciclovir 125 mg · participants with recurrent herpes labialis

Famciclovir showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Famciclovir vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Famciclovir showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

2 findings from 1 review

Famciclovir vs placebo

Duration of attack of recurrent herpes labialis during use of the preventative intervention ‐ famciclovir 125 mg · participants with recurrent herpes labialis

Famciclovir showed no clear difference in duration of attack of recurrent herpes labialis during use of the… compared with placebo (moderate certainty).

1 finding from 1 review

Famciclovir vs placebo

Duration of attack of recurrent herpes labialis during use of the preventative intervention ‐ famciclovir 500 mg · participants with recurrent herpes labialis

Famciclovir probably leads to higher duration of attack of recurrent herpes labialis during use of the… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention (by clinical evaluation) ‐ aciclovir 200 mg 5 times/day · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Severity (aborted lesions) of attack of recurrent herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) showed no clear difference in severity (aborted lesions) of attack of recurrent herpes labialis… compared with placebo (low certainty).

1 finding from 1 review

Topical aciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Topical aciclovir (short‐term) may leads to lower incidence of herpes labialis after use of the preventative… compared with placebo (low certainty).

1 finding from 1 review