Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

Inspiratory muscle training vs control or sham

Health‐related quality of life · patients with chronic obstructive pulmonary disease
2 findings from 1 review

Inspiratory muscle training vs control or sham

Dyspnea · patients with chronic obstructive pulmonary disease
3 findings from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Adverse events (moderate) · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes adverse events moderate adverse events experienced during and after… compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Microbiology Emergence of resistant organisms · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes microbiology Emergence of resistant organisms compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Quality of life: number of participants achieving MCID · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

Summary of findings: Inhaled antibiotics plus IV antibiotics showed no clear difference in quality of life: number of participants achieving MCID compared with IV antibiotics only (low certainty).

1 finding from 1 review