Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,062 questions · 1,113 findings · 171 reviews · Headline outcomes only

No studies found 161 · 14.5%GRADE not reported 41 · 3.7%Very low 269 · 24.2%Low 321 · 28.8%Moderate 252 · 22.6%High 69 · 6.2%

Summary of findings table ‐ Cannabis vs placebo

Spasticity: number of participants reporting reduction of 30% in the spasticity NRS ( · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher spasticity: number of participants reporting reduction of 30% in the… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Participant‐reported pain relief of 50% or greater · health problem or population

It is very uncertain whether summary of findings table ‐ Cannabis changes pain:number of participants reporting pain relief of 50% or greater… compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Patient Global Impression of Change much or very much improved · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher PGIC:number of participants reporting much or very much improvement… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Specific AEs: number of participants reporting drug tolerance ( · health problem or population

It is very uncertain whether summary of findings table ‐ Cannabis changes specific AEs: number of participants reporting drug tolerance ( compared with placebo (very low certainty).

1 finding from 1 review

Dual vs one antiplatelet agent

Stroke, myocardial infarction, or vascular death · preventing early recurrence after ischaemic stroke or TIA

Dual probably leads to lower stroke, myocardial infarction, or vascular death compared with one antiplatelet agent (moderate certainty).

1 finding from 1 review