Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,104 questions · 1,200 findings · 23 reviews · Oral medicine and oral cancer

No studies found 143 · 11.9%GRADE not reported 760 · 63.3%Very low 201 · 16.8%Low 66 · 5.5%Moderate 29 · 2.4%High 1 · 0.1%

Yangyin-humo decoction vs Traditional Western medicine

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Yangyin-humo decoction showed no clear difference in oral mucositis (severe) compared with traditional Western medicine; GRADE not reported.

1 finding from 1 review

Radiotherapy (morning) vs Radiotherapy (afternoon/evening)

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Radiotherapy (morning) showed no clear difference in oral mucositis (moderate to severe) compared with radiotherapy (afternoon/evening); GRADE not reported.

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) led to lower oral mucositis (moderate to severe) compared with no treatment; GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Chinese herbal medicines vs Control (Dobell's solution)

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chinese herbs (medicine) led to lower oral mucositis (moderate to severe) compared with control (Dobell's solution); GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review