Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,741 questions · 1,821 findings · 207 reviews

No studies found 297 · 16.3%GRADE not reported 191 · 10.5%Very low 333 · 18.3%Low 466 · 25.6%Moderate 414 · 22.7%High 120 · 6.6%

Intervention not reported

Socioeconomic effects · individuals without known diabetes mellitus but at high risk for the condition

The review found no eligible studies for this question.

1 finding from 1 review

H. pylori eradication therapy vs control

Incidence of gastric cancer ‐ modified ITT analysis Histological examination · healthy asymptomatic H. pylori‐infected individuals

H. pylori eradication therapy probably leads to lower incidence of gastric cancer ‐ modified ITT analysisHistological… compared with control (moderate certainty).

1 finding from 1 review

H. pylori eradication therapy vs control

Incidence of oesophageal squamous cell carcinoma ‐ modified ITT analysis · healthy asymptomatic H. pylori‐infected individuals

H. pylori eradication therapy showed no clear difference in incidence of oesophageal squamous cell carcinoma ‐ modified ITT… compared with control (moderate certainty).

1 finding from 1 review

Intervention not reported

Other outcomes included uncertainty, pain, sexually related symptoms, dyspnoea, and general symptoms. Data for any of these outcomes were not pooled due to considerable heterogeneity across all aspects. Magnitudes of effect were not reported · individuals with any cancer at any stage
1 finding from 1 review

Standard‐dose VKA plus single antiplatelet agent vs dual antiplatelet agent

Stroke · people with antiphospholipid syndrome, with previous stroke

It is very uncertain whether standard‐dose VKA plus single antiplatelet agent changes stroke compared with dual antiplatelet agent (very low certainty).

1 finding from 1 review

Mepolizumab 100 mg vs placebo

Rate of moderate or severe exacerbations Eosinophilic phenotype · patients with chronic obstructive pulmonary disease

Mepolizumab 100 mg leads to lower rate of moderate or severe exacerbations Eosinophilic phenotype compared with placebo (high certainty).

1 finding from 1 review