Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,703 questions · 15,007 findings · 1,416 reviews

No studies found 2,881 · 19.2%GRADE not reported 1,551 · 10.3%Very low 3,111 · 20.7%Low 3,881 · 25.9%Moderate 2,669 · 17.8%High 914 · 6.1%

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Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to neovascular AMD · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to neovascular AMD compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to geographic atrophy · people with AMD

Antioxidant multivitamin and mineral supplement showed no clear difference in progression to geographic atrophy compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Lutein with or without zeaxanthin vs placebo

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo (low certainty).

1 finding from 1 review

Any cranberry product vs placebo or control

Symptomatic, culture‐verified UTI Elderly men and women in institutions · preventing UTI

Any cranberry product showed no clear difference in symptomatic, culture‐verified UTI Elderly men and women in… compared with placebo or control (moderate certainty).

1 finding from 1 review