Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,310 questions · 1,358 findings · 214 reviews

No studies found 230 · 16.9%GRADE not reported 169 · 12.4%Very low 269 · 19.8%Low 277 · 20.4%Moderate 291 · 21.4%High 122 · 9%

Intervention not reported

Cyclosporin A (2 RCTs; 49 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (2 RCTs; 49 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 13 RCTsTotal participants: 1658 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Corticosteroid (1 RCT; 21 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes corticosteroid (1 RCT; 21 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Dupilumab (4 RCTs; 990 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes dupilumab (4 RCTs; 990 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cyclosporin A (3 RCTs; 74 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (3 RCTs; 74 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Timapiprant (1 RCT; 70 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in timapiprant (1 RCT; 70 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Total studies: 6 RCTsTotal participants: 2680 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

CIM331 (1 RCT; 27 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in CIM331 (1 RCT; 27 participants) (low certainty).

1 finding from 1 review

Intervention not reported

GBR830 (1 RCT; 46 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in GBR830 (1 RCT; 46 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Azathiopine (AZA) (1 RCT; 41 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in azathiopine (AZA) (1 RCT; 41 participants) (low certainty).

1 finding from 1 review

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QAW039 (1 RCT; 76 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

CsAI (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes csAI (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 17 RCTsTotal participants: 3972 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

The intervention probably leads to lower QAW039 (1 RCT; 76 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

Dupilumab (9 RCTs; 1663 participants) · patients with moderate to severe eczema

The intervention may leads to lower dupilumab (9 RCTs; 1663 participants) (low certainty).

1 finding from 1 review