Cognitive impairment · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes cognitive impairment at 18‐24 months compared with phenobarbital alone (very low certainty).
1 finding from 1 review
Need for mechanical ventilation · neonates with EEG‐confirmed seizures
1 finding from 1 review
no estimate extracted
1 study · 1 participants
GRADE not reported
Mortality before hospital discharge · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with levetiracetam (very low certainty).
1 finding from 1 review
Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes proportion of infants who develop epilepsy post‐discharge compared with phenobarbital alone (very low certainty).
1 finding from 1 review
Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Lignocaine changes proportion of infants who achieve seizure control after maximal… compared with benzodiazepines (very low certainty).
1 finding from 1 review
Mortality or neurodevelopmental disability at 12 months · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Lignocaine changes mortality or neurodevelopmental disability at 12 months compared with benzodiazepines (very low certainty).
1 finding from 1 review
Mortality before hospital discharge · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Lignocaine changes mortality before hospital discharge compared with benzodiazepines (very low certainty).
1 finding from 1 review
Neurodevelopmental disability · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Lignocaine changes neurodevelopmental disability at 12 months compared with benzodiazepines (very low certainty).
1 finding from 1 review
Proportion of infants with repeat seizure before hospital discharge · neonates with clinically diagnosed seizures
It is very uncertain whether summary of findings table ‐ Maintenance ASM changes proportion of infants with repeat seizure before hospital discharge compared with no maintenance ASM after achieving seizure control (very low certainty).
1 finding from 1 review
Mortality or neurodevelopmental disability at 18 to 24 months' corrected age ‐ not reported · neonates with clinically diagnosed seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mortality before hospital discharge · neonates with clinically diagnosed seizures
Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality before hospital discharge compared with no maintenance ASM after achieving seizure control (low certainty).
1 finding from 1 review
Mortality at 18‐24 months · neonates with clinically diagnosed seizures
Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).
1 finding from 1 review
Need for mechanical ventilation · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital changes requirement of mechanical ventilation compared with levetiracetam (very low certainty).
1 finding from 1 review
Neurodevelopmental disability at 18 to 24 months among survivors · neonates with clinically diagnosed seizures
Summary of findings table ‐ Maintenance ASM showed no clear difference in neurodevelopmental disability at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).
1 finding from 1 review
Proportion of infants who develop epilepsy post‐discharge · neonates with clinically diagnosed seizures
Summary of findings table ‐ Maintenance ASM showed no clear difference in proportion of infants who develop epilepsy post‐discharge compared with no maintenance ASM after achieving seizure control (low certainty).
1 finding from 1 review
Seizure burden during hospitalisation · neonates
1 finding from 1 review
Mortality or neurodevelopmental disability at 18 to 24 months' corrected age ‐ not reported · neonates
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mortality before hospital discharge · neonates
Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in mortality before hospital discharge compared with treatment of clinical seizures alone (low certainty).
1 finding from 1 review
Proportion of infants who develop epilepsy post‐discharge · neonates
Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in proportion of infants who develop epilepsy post‐discharge compared with treatment of clinical seizures alone (low certainty).
1 finding from 1 review