Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Phenobarbital vs levetiracetam

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes proportion of infants who develop epilepsy post‐discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Lignocaine vs benzodiazepines

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes proportion of infants who achieve seizure control after maximal… compared with benzodiazepines (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Lignocaine vs benzodiazepines

Mortality or neurodevelopmental disability at 12 months · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes mortality or neurodevelopmental disability at 12 months compared with benzodiazepines (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Proportion of infants with repeat seizure before hospital discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Maintenance ASM changes proportion of infants with repeat seizure before hospital discharge compared with no maintenance ASM after achieving seizure control (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality before hospital discharge · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality before hospital discharge compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality at 18‐24 months · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Need for mechanical ventilation · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes requirement of mechanical ventilation compared with levetiracetam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Neurodevelopmental disability at 18 to 24 months among survivors · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in neurodevelopmental disability at 18‐24 months compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Proportion of infants who develop epilepsy post‐discharge · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in proportion of infants who develop epilepsy post‐discharge compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Treatment of clinical and electrographic seizures vs treatment of clinical seizures alone

Mortality before hospital discharge · neonates

Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in mortality before hospital discharge compared with treatment of clinical seizures alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Treatment of clinical and electrographic seizures vs treatment of clinical seizures alone

Proportion of infants who develop epilepsy post‐discharge · neonates

Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in proportion of infants who develop epilepsy post‐discharge compared with treatment of clinical seizures alone (low certainty).

1 finding from 1 review