Doxycycline 40 mg vs placebo
Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsHigh
Findings
What do systematic reviews say?
1,057 questions · 1,077 findings · 32 reviews · Skin
No studies found 395 · 36.7%GRADE not reported 89 · 8.3%Very low 172 · 16%Low 177 · 16.4%Moderate 191 · 17.7%High 53 · 4.9%
Doxycycline 40 mg vs placebo
Assessment of erythema or telangiectasia · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsHigh
Doxycycline 40 mg vs placebo
Lesion count · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsModerate
Doxycycline 40 mg vs placebo
Time needed until improvement of the skin lesions · Participants with rosacea
1 finding from 1 review
- no estimate extracted2 studies · 537 participantsHigh
Metronidazole vs placebo
Duration of remission · Participants with rosacea
Metronidazole probably leads to lower duration of remission compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.5 [0.25, 0.99]1 study · 88 participantsModerate
Doxycycline 40 mg vs placebo
Duration of remission ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azithromycin vs doxycycline
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azithromycin vs doxycycline
Participant‐assessed improvement in rosacea severity · Participants with rosacea
It is very uncertain whether azithromycin changes participant‐assessed improvement in rosacea severity compared with doxycycline 100 mg (very low certainty).
1 finding from 1 review
- RR 0.98 [0.77, 1.25]1 study · 67 participantsVery low
Azithromycin vs doxycycline
Proportion of participants with adverse event · Participants with rosacea
It is very uncertain whether azithromycin changes proportion of participants with adverse event compared with doxycycline 100 mg (very low certainty).
1 finding from 1 review
- RR 1.62 [0.32, 8.26]1 study · 67 participantsVery low
Azithromycin vs doxycycline
Physician‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azithromycin vs doxycycline
Assessment of erythema or telangiectasia ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azithromycin vs doxycycline
Lesion count · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 67 participantsVery low
Azithromycin vs doxycycline
Time needed until improvement of the skin lesions · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azithromycin vs doxycycline
Duration of remission · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 67 participantsVery low
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azelaic acid vs placebo
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Proportion of participants with adverse event · Participants with rosacea
Doxycycline 40 mg + metronidazole 1% gel may leads to lower proportion of participants with adverse event compared with doxycycline 100 mg + metronidazole 1% gel (low certainty).
1 finding from 1 review
- RR 0.25 [0.11, 0.54]1 study · 91 participantsLow
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Assessment of erythema or telangiectasia · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow